yu-sang li
professor
e-mail :
team website:
tel: 86-27- 67842332
ucurriculum vitae
•hunan college of traditional chinese medicine, clinical medicine, 1997
•hiroshima university, hiroshima, japan, m.d., 2006
•hiroshimauniversityhospital, hiroshima, japan, researcher assistant, 2006-2007
•hiroshimauniversity, hiroshima, japan, visiting researcher, 2008-2009
•south-centraluniversity for nationalities, associate professor, 2009-2016
•south-centraluniversity for nationalities, professor, since 2016
uresearch interests
•molecular mechanism of liver cancer;
•pharmacological research on anti-cancer, anti-inflammatory and analgesic activity of traditional chinese medicine;
•mechanism of chronic pain.
uassociation and awards
•the japan breast cancer society, member;
•the japanese society of pathology, member;
•the first prize, the 13th general meeting of japan breast cancer society, 2005;
•the first prize, the 8th excellent thesis award of japan breast cancer society, 2007
urepresentative publications (*corresponding author)
1.zhang mt, ye xx, lan w, yang yl, wu t, li ys*, tang hb.strategic combination of isocratic and gradient elution for simultaneous separation of polar compounds in traditional chinese medicines by hplc.journal of analytical methods in chemistry, 2018 (2018): 7569283, doi.org/10.1155/2018/7569283.
2.chen mt, yang yj, li ys, li xj, zhang wk, wang jp, wang x, tian gh, tang hb*. shengfu oil enhances the healing of full-thickness scalded skin accompanying the differential regulation of β-catenin, dlk1, and cox-2. frontiers in pharmacology. 2017 nov 6; 8: 801. doi: 10.3389/fphar.2017.00801. ecollection 2017.
3.ning d, zhang wk, tian h, li xj, liu m, li ys*, tang hb. the involvement of β-catenin/cox-2/vegf axis in nmda-caused retinopathy. journal of ophthalmology. 2017; 2017: 9760501. doi: 10.1155/2017/9760501.
4.li xj, mu ym, qin qf, zeng zx, li ys, zhang wk, tang hb*, tian gh, shang hc. chronic high-dosage fish oil exacerbates gut-liver axis injury in alcoholic steatohepatitis in mice: the roles of endotoxin and il-4 in kupffer cell polarization imbalance. toxicology research. 2017, 6, 611-620.doi: 10.1039/c7tx00037e
5.zhang wk, gu hw, li xj, li ys, tang hb*, tian gh, shang hc. the dark side of the force - lipid nanoparticles enhance the oncogenesis of diethylnitrosamine and result in liver cancer in mice. nanomedicine: nanotechnology, biology, and medicine. 2017, 13(2): 701-711. doi: 10.1016/j.nano.2016.09.017.
6.li ys, leng cl, chen mt, zhang wk, li xj, tang hb*, shang hc, zhu lh. mouse hepatic neoplasm formation induced by trace level and low frequency exposure to diethylnitrosamine through β-catenin signaling pathway. toxicology research. 2016, 5:210-223.
7.li xj, yang yj, li tt, li ys, zhang wk, tang hb*. α-pinene, linalool, and 1-octanol contribute to the topical anti-inflammatory and analgesic activities of frankincense by inhibiting cox-2. journal of ethnopharmacology. 2016, 179:22-26.
8.yang yl, ye xx, li ys*, tan zf, jiang jz. determination of morphine in pharmaceutical products by on-line solid-phase extraction and high-performance liquid chromatography. analytical letters. 2016, 49: 1303-1309, doi.org/10.1080/00032719.2015.1101603.
9.li xj, mu ym, li tt, yang yl, zhang mt, li ys, zhang wk, tang hb*, shang hc. gynura procumbens reverses acute and chronic ethanol-induced liver steatosis through mapk/srebp-1c-dependent and -independent pathways. journal of agricultural and food chemistry. 2015, 63(38):8460-8471.
10.li ys, xi y, li xj, leng cl, jia mm, zhang wk, tang hb*. up-regulation of the biosynthesis and release of substance p through wnt/β-catenin signaling pathway in rat dorsal root ganglion cells. plos one. 2015, 10(6): e0129701.
11.zhao xj, chen q, li ys*, tang hb, liu w, yang xl. doxorubicin and curcumin co-delivery by lipid nanoparticles for enhanced treatment of diethylnitrosamine-induced hepatocellular carcinoma in mice. european journal of pharmaceutics and biopharmaceutics. 2015, 93: 27-36.
12.zhao xj, chen q, liu w, li ys*, tang hb, liu xh, yang xl. co-delivery of doxorubicin and curcumin withlipid nanoparticles results in improved efficacy of chemotherapy in liver cancer. international journal of nanomedicine. 2015, 10: 257–270.
13.li ys, chen bf, li xj, zhang wk, tang hb*. cytotoxicity of polyaniline nanomaterial on rat celiac macrophages in vitro. plos one. 2014, 9(9):e107361.
14.li xj, jia mm, li ys*, yang yl, mao xq, tang hb. involvement of substance p/neurokinin-1 receptor in the analgesic and anticancer activities of minimally toxic fraction from the traditional chinese medicine liu-shen-wan in vitro. biological and pharmaceutical bulletin. 2014, 37(3):431-438.
15.xi y, li ys*, tang hb. high mobility group a1 protein acts as a new target of notch1 signaling and regulates cell proliferation in t leukemia cells. molecular and cellular biochemistry. 2013, 374: 173-180.
16.li ys, wang jx, jia mm, liu m, li xj, tang hb*. dragon's blood inhibits chronic inflammatory and neuropathic pain responses by blocking the synthesis and release of substance p in rats. journal of pharmacological sciences. 2012,118: 43-54.
17.li ys, liu m, nakata y, tang hb. β-catenin accumulation in nuclei of hepatocellular carcinoma cells up-regulates glutathione-s-transferase m3 mrna. world journal of gastroenterology. 2011, 17:1772.
18.luo w, li ys*, yuan j, zhu lh, liu zd, tang hq. ultrasensitive fluorometric determination of hydrogen peroxide and glucose by using multiferroic bifeo3 nanoparticles as a catalyst. talanta. 2010, 81: 901.
19.li ys, kaneko m, amatya vj, takeshima y, arihiro k, inai k*. expression of vascular endothelial growth factor-c and its receptor in invasive micropapillary carcinoma of the breast. pathology international. 2006, 56 : 256.
20.li ys, kaneko m, sakamoto dg, takeshima y, inai k*. the reversed apical pattern of muc1 expression is characteristics of invasive micropapillary carcinoma of the breast. breast cancer. 2006, 13: 58.
urepresentative grants
1.grant from national natural science foundation of china: protective mechanisms of gynura procumbens against liver cancer through the inhibition of inflammatory feedback loop of “β-catenin/cox-2, no. 81673711, 2016;
2.grant from national natural science foundation of china: a study on the mechanism of cancer pain relief by liu-shen-wan through the inhibition of the β-catenin and cox-2 regulatory loop, no. 81573887, 2015;
3.grant from national natural science foundation of china: moduation mechanism of huoxuequyu compound on diabetic retinopathy base on wnt/β-catenin signaling pathway, no. 81202942, 2012;
4.grant from national natural science foundation of china: the regulatory role of wnt/β-catenin signaling pathway in the development of primary hepatocellular carcinoma, no. 81101538, 2011;
5.grant from national natural science foundation of china: the role of non-neuronal cells in the regulation of substance p release from dorsal root ganglion neurons, no. 81070887, 2010;
6.tackle key projects in science and technology of wuhan city, china: pre-clinical research of dadou jiangtangwan on type ii diabetes treatment, no. 201060623266, 2010
