education
2000-2004: b.s., college of life sciences, northwest a&f university.
2004-2009: m.s. & ph.d., the state key laboratory of phytochemistry and plant resources in west china, kunming institute of botany, cas.
professional experiences
2019.3-present: professor, school of pharmaceutical science, south-central university for nationalities
2016.2-2019.2: professor, school of pharmaceutical science, chongqing university
2014.5-2015.5: postdoctoral fellow, institute of organic chemistry, hannover university
2012.4-2014.4: jsps fellow, graduate school of pharmaceutical sciences, the university of tokyo
2009.9-2016.1: associate professor, college of pharmaceutical science, hebei university
research interests
[1] multiple strategies-guided fungal natural products discovery from fungi of unique ecological niches and their biological function investigations.
[2] the biosynthesis of fungal natural products (genome mining, engineered biosynthesis).
selected recent publications
[1] xiao-long yang, steffen friedrich, sen yin, oliver piech, katherine williams, thomas j. simpson, russell j. cox*. molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase. chemical science, 2019, 10, 8478–8489.
[2] lu-lin xu#, hai-li chen#, ping hai, yuan gao, chuan-dong xie, xiao-long yang*, ikuro abe*. ( )- and ()-preuisolactone a: a pair of caged norsesquiterpenoidal enantiomers with a tricyclo[4.4.01,6.02,8]decane carbon skeleton from the endophytic fungus preussia isomera. organic letters, 2019, 21, 10781081.
[3] lu-lin xu, ping hai, shuai-bing zhang, jing-fang xiao, yuan gao, bing-ji ma, hai-yan fu*, ye-miao chen*, xiao-long yang*. prenylated indole diterpene alkaloids from a mine soil-derived tolypocladium sp. journal of natural products, 2019, 82: 221-231.
[4] heng-ye chen#, ting-kai liu#, jian yang,* xiao-long yang*. emerones a-c: three novel merosesquiterpenoids with unprecedented skeletons from emericella sp. xl029. organic & biomolecular chemistry, 2019, 17: 8450 -8455.
[5] sheng-xiang yang#, wen-ting zhao#, heng-ye chen, lei zhang, ting-kai liu, he-ping chen*, jian yang*, xiao-long yang*. two new c13-polyketides from chaetomium globosum, an endophytic fungus in salvia miltiorrhiza. chemistry & biodiversity, 2019, 16: e1900364.
[6] sheng-xiang yang#, jing-fang xiao#, ting-kai liu, ze-diao huang, xiang li, ye-miao chen*, xiao-long yang*. epitajixanthone hydrate: a new inhibitor of cancer cell growth and invasion. anti-cancer drugs, 2019, in press.
[7] wei zhao, hai-li chen, liu hong, xia zhang, xian-jun jiang, dong-lai zhu*, fei wang*, xiao-long yang*. five new polyphenolic derivatives with antimicrobial activities from the root barks of periploca sepium. fitoterapia, 2019, 137: 104254.
[8] heng-ye chen, ting-kai liu, qiong shi, xiao-long yang*. sesquiterpenoids and diterpenes with antimicrobial activity from leptosphaeria sp. xl026, an endophytic fungus in panax notoginseng. fitoterapia, 2019, 137: 104243.
[9] lu-lin xu#, xue-jiao pang#, qiong shi, peng-jie xian, yan-duo tao*, xiao-long yang*. two new prenylated indole diterpenoids from tolypocladium sp. and their antimicrobial activities. chemistry & biodiversity, 2019, 16: e1900116.
[10] wen-ting zhao#, xiong shi#, peng-jie xian, zhang feng*, jian yang*, xiao-long yang*. a new fusicoccane diterpene and a new polyene from the plant endophytic fungus talaromyces pinophilus and their antimicrobial activities. natural product research, 2019, doi: 10.1080/14786419.2019.1616727.
[11] dan xu, xia zhang, xiong shi, peng-jie xian, liu hong, yan-duo tao*, xiao-long yang*. two new cytochalasans from the marine sediment-derived fungus westerdykella dispersa and their antibacterial activities. phytochemistry letters, 2019, 32: 52-55.
[12] xia zhang#, hai-li chen#, liu hong, lu-lin xu, xiao-wei gong, dong-lai zhu, xiao-hua xu, wei zhao*, fei wang*, xiao-long yang*. three new hopane-type triterpenoids from the aerial part of adiantum capillus-veneris and their antimicrobial activities. fitoterapia, 2019, 133: 146-149.
[13] ting zhao, lu-lin xu, yan zhang, zheng-hong lin, tao xia, deng-feng yang*, ye-miao chen*, xiao-long yang *. three new α-pyrone derivatives from the plant endophytic fungus penicillium ochrochloronthe and their antibacterial, antifungal and cytotoxic activities. journal of asian natural products research, 2019, 21: 851-858.
[14] xue-jiao pang, shuai-bing zhang, peng-jie xian, xia wu, deng-feng yang*, hai-yan fu*, xiao-long yang*. emericellins a and b: two sesquiterpenoids with an unprecedented tricyclo[4,4,2,1]hendecane scaffold from the liquid cultures of endophytic fungus emericella sp. xl 029. fitoterapia, 2018, 131: 55-58.
[15] wei zhao, lu-lin xu, xia zhang, xiao-wei gong, dong-lai zhu, xiao-hua xu, fei wang*, xiao-long yang*. three new phenanthrenes with antimicrobial activities from the aerial parts of juncus effuses. fitoterapia, 2018, 130: 247-250.
[16] xia wu, xue-jiao pang, lu-lin xu, qiong-yin zhang, xin-yu long, hai-li qin, deng-feng yang*, xiao-long yang*. two new alkylated furan derivatives with antifungal and antibacterial activities from the plant endophytic fungus emericella sp. xl029. natural product research, 2018, 32: 2625-2631.
[17] xue-jiao pang#, shuai-bing zhang#, hai-li chen, wen-ting zhao, deng-feng yang, peng-jie xian, lu-lin xu, yan-duo tao*, hai-yan fu*, xiao-long yang*. emericelactones a-d: four novel polyketides produced by emericella sp. xl 029, a fungus associated the leaves of panax notoginseng. tetrahedron letters, 2018, 59: 4566-4570.
[18] wei zhao, xiao-wei gong, yuan-xing duan, ji yang, xia wu, xian-jun jiang, xiao-hua xu, yong-kuan chen, liu yang*, fei wang*, xiao-long yang*. two new triterpenoids with antimicrobial activity from the leaves and twigs of orophea yunnanensis. natural product research, 2018, doi: 10.1080/14786419.2018.1481843.
[19] dan xu, ming-he luo, feng-lou liu, dong wang, xue-jiao pang, ting zhao, lu-lin xu, xia wu, ming-yu xia*, xiao-long yang*. cytochalasan and tyrosine-derived alkaloids from the marine sediment-derived fungus westerdykella dispersa and their bioactivities. scientific reports, 2017, 7:11956-11964.
[20] xia wu, li-zhen fang, feng-lou liu, xue-jiao pang, hai-li qin, ting zhao, lu-lin xu, deng-feng yang, xiao-long yang*. new prenylxanthones, polyketide hemiterpenoid pigments from the endophytic fungus emericella sp. xl029 and their anti-agricultural pathogenic fungal and antibacterial activities. rsc advances, 2017, 7, 31115-31122.
[21] dan xu, xue-jiao pang, ting zhao, lu-lin, xiao-long yang*. new alkenylated tetrahydropyran derivatives from the marine sediment-derived fungus westerdykella dispersa and their bioactivities. fitoterapia, 2017, 122:45-51.
[22] feng-lou liu, and xiao-long yang*. indole derivatives produced by the metagenome genes of the escherichia coli-harboring marine sponge discodermia calyx. molecules, 2017, 22: 681.
