zheng yongsheng, ph. d. associate professor
research interests: organic synthesis and medicinal chemistry
e-mail：zhysh3811@163.com orcid：0000-0002-1019-5521
education and professional training
2016/08-present：school of pharmaceutical sciences, lecturer, associate professor、master supervisor
2013/08-2015/07：university of central florida
advisor: professor yuan yu
2010/09-2013/07：chinese academy of science, chengdu institute of organic chemistry, ph.d. in organic chemistry, research advisor: zhang xiaomei
2007/09-2010/07：west china school of pharmacy, sichuan university, m.a. in medicinal chemistry, research advisor: chen li
2002/09-2006/07：xihua university b.s. in pharmaceutical engineering
teaching
medicinal chemistry、medicinal chemistry experiment
fund
1. national natural science foundation of china，82574290，2026/01-2029/12
2. national natural science foundation of china，81973208，2020/01-2023/12，
3. hubei provincial natural science foundation of china，bzy18013，2019/01-2020/12
4.the fundamental research funds for the central universities，czq20011, 2020/1-2021/12
5.the fundamental research funds for the central universities，czq17010，2017/01-2018/12
publications：
1. luoqin luo, limei gao, dongqing he, yuting tian, jikai liu,* yongsheng zheng*, cooperative pd/chiral secondary amine enabled diastereo- and enantioselective [3 2] cycloannulation: synthesis of polysubstituted cyclopentanes, org. lett., 2025, 27, 1847−1852.
2. hui guo, yuqi tian, xing wu, liang tu, jikai liu*, yongsheng zheng*, rong huang*, efficient assembly and anti-tumor evaluation of novel polycyclic [1,2-a]-fused indoles. bioorganic chemistry. 2024, 146, 107289.
3. liang tu, sen li, li-mei gao,* bo-wei tang, yong-sheng zheng,* and ji-kai liu*, cooperative rh/achiral phosphoric acid-enabled [3 3] cycloannulation of carbonyl ylides with quinone monoimines: synthesis of benzofused dioxabicyclo[3.2.1]octane scaffolds. j. org. chem. 2024, 89, 9031−9042.
4. xi luo, sen li, yuting tian, yuqi tian, limei gao, qiang wang,* yongsheng zheng,* atroposelective construction of naphthylpyrazoles by chiral phosphoric acid catalyzed enantioselective cross-coupling of pyrazoles with naphthoquinone esters, eur. j. org. chem. 2024, 27 (23), e202400254.
5. yuting tian, ziyang chen, kexin su, yongsheng zheng,* and jikai liu,*[2 2 1 1] cycloaddition reaction of 1,3,5-triazinanes with methylene compounds: approach to hexahydropyrimidines. adv. synth. catal. 2023, 365, 3909–3914.
6. yuting tian 1,†, dongqing he 2,†, limei gao*, yu zou, xiaoshuang liu, qiang wang, enxiang liang* and yongsheng zheng*, regioselective reaction of 2-indolylmethanols with enamides. molecules, 2023, 28, 3341.
7. qinglang wei , liang tu , sen li, yongsheng zheng,* and jikai liu,*palladium-catalyzed [4 2] cycloaddition of vinylbenzoxazinanones with 1,3-indanedione: approach tospiro-tetrahydroquinoline scaffolds. eur. j. org. chem. 2023, 26, e202300499.
8. liang tu, limei gao, qiang wang, zhixing cao, rong huang, yongsheng zheng,* and jikai liu*, substrate-switched chemodivergent pyrazole and pyrazoline synthesis: [3 2] cycloaddition/ring-opening rearrangement reaction of azadienes with nitrile imines. j. org. chem. 2022, 87, 3389−3401.
9. limei . gao , xiaomeng wang , qinglang wei, kexin su, renhong huang, ju guo, yongsheng zheng,* and jikai liu,* [3 3] cycloadditions of azomethine ylides with nitrile imines for the synthesis of 2,3,4,5-tetrahydro-1,2,4-triazine-5-carboxylates, eur. j. org. chem. 2022, e202200768.
10. limei gao, ruijie shi, yuting tian, xi luo, yongsheng zheng, and qiang wang. synthesis of pyrazoles through [3 2] cyclization of nitrile imines with cinnamaldehydes followed by air oxidation. chemistryselect 2021, 6, 12838–12842.
11. ruijie shi, limei gao, weiji chen, yangqing shi, zhixing cao, yongsheng zheng,* and jikai liu*. formal [2 2 2] cycloaddition reaction of 1,3,5-triazinanes with diethyl acetylene dicarboxylate: approach to tetrahydropyrimidines. eur. j. org. chem. 2021, 44, 5941–5945.
12. liang tu, limei gao, xiaomeng wang, ruijie shi, rupei ma, junfei li, xiaoshuang lan, yongsheng zheng,* and jikai liu,* [3 2] cycloaddition of nitrile imines with enamides: an approach to functionalized pyrazolines and pyrazoles. j. org. chem. 2021, 86(1), 559−573.
13. na li, liang tu, guiguang cheng, houling sa, zhenghui li, tao feng, yongsheng zheng,* jikai liu.* diastereoselective [3 3] cycloaddition reaction of 2-arylideneindan-1,3-diones with b-naphthols: efficient assemble of immunosuppressive pentacyclic chromanes. tetrahedron letters. 2020, 61(10), 151579-151587.(if 2.275)
14. y. s. zheng, l. tu, n. li, r. huang, t. feng, h. sun, z. h. li, j. k. liu, inverse-electron-demand [4 2]-cycloaddition of 1,3,5-triazinanes: facile approaches to tetrahydroquinazolines. advanced. synthesis & catalyst. 2019, 361(1), 44-48.
15. l. tu, z. h. li, t. feng, s. y. yu, r. huang, j. li, w. x. wang, y. s. zheng,* j. k. liu,* access to imidazolidines via 1,3-dipolar cycloadditions of 1,3,5-triazinanes with aziridine. the journal of organic chemistry. 2019, 84(17), 11161-11169.
16. y. s. zheng, l. tu, l. m. gao, r. huang, t. feng, h. sun, w. x. wang, z. h. li, j. k. liu. accessing benzooxadiazepines via formal [4 3] cycloadditions of aza-o-quinone methides with nitrones. organic & biomolecular chemistry, 2018, 16(15), 2639-2642.
17. z.y. chu, n. li, d. liang, z. h. li, y.s. zheng,* j. k. liu. accessing substituted pyrrolidines via formal [3 2] cycloaddition of 1,3,5-triazinanes and donor-acceptor cyclopropanes. tetrahedron letters. 2018, 59(8), 715-718. (if 2.125)
18. y. s. zheng, j. cleaveland, d, richardson. y. yuan. “an oganocatalysis based carbocyclic spiroindoline synthesis enables facile sar study at c-2 position”. organic. letters. 2015, 17(17), 4240–4243.
19. yongsheng zheng, ebrahim h. ghazvini zadeh, yu yuan. one-pot, enantioselective synthesis of 2,3-dihydroazulen-6(1h)-one: a concise access to the core structure of cephalotaxus norditerpenes. european journal of organic chemistry. 2016, 2016(12), 2115–2119.
20. yongsheng zheng, muqiong liu, yu yuan. a very mild and selective method for o-benzoylation of hydroxamic acids. tetrahedron letters. 2014. 55 (31). 4404-4406.
21. y. s. zheng, z. y. xue, l. x. liu, c. shu, w. c. yuan, x. m. zhang. highly enantioselective hydrosilylation of n-(1,2-diphenylethylidene)arylamines. organic & biomolecular chemistry. 2013, 11(3), 412-415.
