b.s., 09/2000-07/2004
school of pharmacy, wuhan university, wuhan, hubei, p. r. china
major: pharmacy
ph.d., 09/2004-11/2009
department of medicinal chemistry, school of pharmacy, shandong university, jinan, shandong, p. r. china
major: medicinal chemistry
lecturer, 01/2010-05/2013
college of pharmacy, south-central university for nationalities
associate professor, 01/2010-present
college of pharmacy, south-central university for nationalities
visiting scholar, 12/2014-12/2015
department of chemistry, georgia state university, atlanta, georgia, america
major: medicinal chemistry
research interests:
1.cadd
2.antitumor drugs
list of publications:
[1] q. wang, q. shi, l. huang, novel aminopeptidase n inhibitors with improved antitumor activities, lett drug des discov, 13 (2016) 98-106.
[2] l. zhang, y. han, q. jiang, c. wang, x. chen, x. li, f. xu, y. jiang, q. wang, w. xu, trend of histone deacetylase inhibitors in cancer therapy: isoform selectivity or multitargeted strategy, medicinal research reviews, 35 (2015) 63-84.
[3] x. song, z. zhao, x. qi, s. tang, q. wang, t. zhu, q. gu, m. liu, j. li, identification of epipolythiodioxopiperazines hdn-1 and chaetocin as novel inhibitor of heat shock protein 90, oncotarget, 6 (2015) 5263-5274.
[4] l. shuai, z. chen, p. fei, q. wang, t. yang, spectroscopic analysis on the interaction of ferulic acid and tetramethylpyrazine with trypsin, luminescence : the journal of biological and chemical luminescence, 29 (2014) 79-86.
[5] h. gao, w. guo, q. wang, l. zhang, m. zhu, t. zhu, q. gu, w. wang, d. li, aspulvinones from a mangrove rhizosphere soil-derived fungus aspergillus terreus gwq-48 with anti-influenza a viral (h1n1) activity, bioorganic & medicinal chemistry letters, 23 (2013) 1776-1778.
[6] j. zhang, x. pan, c. wang, f. wang, p. li, w. xu, l. he, pharmacophore modeling, 3d-qsar studies, and in-silico adme prediction of pyrrolidine derivatives as neuraminidase inhibitors, chemical biology & drug design, 79 (2012) 353-359.
[7] q. li, h. fang, x. wang, g. hu, q. wang, w. xu, novel potent 2,5-pyrrolidinedione peptidomimetics as aminopeptidase n inhibitors. design, synthesis and activity evaluation, bioorganic & medicinal chemistry letters, 22 (2012) 850-853.
[8] l. zhang, h. zhu, q. wang, h. fang, w. xu, m. li, homology modeling, molecular dynamic simulation and docking studies of cyclin dependent kinase 1, journal of molecular modeling, 17 (2011) 219-226.
[9] j. su, q. wang, j. feng, c. zhang, d. zhu, t. wei, w. xu, l. gu, engineered thermoplasma acidophilum factor f3 mimics human aminopeptidase n (apn) as a target for anticancer drug development, bioorganic & medicinal chemistry, 19 (2011) 2991-2996.
[10] y. luan, q. wang, n. liu, j. mou, x. jiao, h. fang, m. li, w. xu, synthesis and activity evaluation of a new bestatin derivative lyp2 as an aminopeptidase n inhibitor, anti-cancer drugs, 22 (2011) 99-103.
[11] j. mou, h. fang, y. liu, l. shang, q. wang, l. zhang, w. xu, design, synthesis and primary activity assay of bi- or tri-peptide analogues with the scaffold l-arginine as amino-peptidase n/cd13 inhibitors, bioorganic & medicinal chemistry, 18 (2010) 887-895.
[12] k. yang, q. wang, l. su, h. fang, x. wang, j. gong, b. wang, w. xu, design and synthesis of novel chloramphenicol amine derivatives as potent aminopeptidase n (apn/cd13) inhibitors, bioorganic & medicinal chemistry, 17 (2009) 3810-3817.
[13] l. shang, h. fang, h. zhu, x. wang, q. wang, j. mu, b. wang, s. kishioka, w. xu, design, synthesis and sar studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase n/cd13 inhibitors, bioorganic & medicinal chemistry, 17 (2009) 2775-2784.
[14] j. mou, h. fang, f. jing, q. wang, y. liu, h. zhu, l. shang, x. wang, w. xu, design, synthesis and primary activity evaluation of l-arginine derivatives as amino-peptidase n/cd13 inhibitors, bioorganic & medicinal chemistry, 17 (2009) 4666-4673.
[15] y. liu, l. shang, h. fang, h. zhu, j. mu, q. wang, x. wang, y. yuan, w. xu, design, synthesis, and preliminary studies of the activity of novel derivatives of n-cinnamoyl-l-aspartic acid as inhibitors of aminopeptidase n/cd13, bioorganic & medicinal chemistry, 17 (2009) 7398-7404.
[16] x. li, y. wang, j. wu, y. li, q. wang, w. xu, novel aminopeptidase n inhibitors derived from antineoplaston as2-5 (part ii), bioorganic & medicinal chemistry, 17 (2009) 3061-3071.
[17] j. zhang, q. wang, h. fang, w. xu, a. liu, g. du, design, synthesis, inhibitory activity, and sar studies of hydrophobic p-aminosalicylic acid derivatives as neuraminidase inhibitors, bioorganic & medicinal chemistry, 16 (2008) 3839-3847.
[18] q. wang, m. chen, h. zhu, j. zhang, h. fang, b. wang, w. xu, design, synthesis, and qsar studies of novel lysine derives as amino-peptidase n/cd13 inhibitors, bioorganic & medicinal chemistry, 16 (2008) 5473-5481.
[19] l. shang, q. wang, h. fang, j. mu, x. wang, y. yuan, b. wang, w. xu, novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase n (apn), bioorganic & medicinal chemistry, 16 (2008) 9984-9990.
[20] j. zhang, q. wang, h. fang, w. xu, a. liu, g. du, design, synthesis, inhibitory activity, and sar studies of pyrrolidine derivatives as neuraminidase inhibitors, bioorganic & medicinal chemistry, 15 (2007) 2749-2758.
[21] l. zhang, j. zhang, h. fang, q. wang, w. xu, design, synthesis and preliminary evaluation of new cinnamoyl pyrrolidine derivatives as potent gelatinase inhibitors, bioorganic & medicinal chemistry, 14 (2006) 8286-8294.
